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Epilepsy: A Comprehensive Textbook 3rd Edition PDF

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Here’s the complete overview of Epilepsy: A Comprehensive Textbook 3rd Edition PDF:

Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.

Features of Epilepsy: A Comprehensive Textbook 3rd Edition PDF

Here’s a quick overview of the essential features of this book:

  • Offers a thorough discussion of epileptic seizure types and epilepsy syndromes, reflecting the latest research and knowledge throughout
  • Discusses major advances in the understanding of the basic mechanisms of epilepsy and seizures, including an expanded section on their genetic etiologies, their consequences and co-occurring conditions.
  • Presents state-of-the-art approaches for the diagnostic evaluation of individuals with seizures, pharmacotherapy and alternative treatments, and extensive discussions of the new antiseizure medications for managing seizure intensity and frequency, along with their side effects
  • Covers the latest developments in surgical approaches to treatment, including neuromodulation
  • Discusses psychiatric issues associated with epilepsy and conditions resembling seizures.
  • Presents the current state of global health care delivery for individuals with epilepsy
  • Shares the knowledge and expertise of contributing authors from 48 countries and nearly 300 institutions

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Table of Contents

Below is the complete table of contents offered inside Epilepsy: A Comprehensive Textbook 3rd Edition PDF:

Section Editors: Alexis Arzimanoglou, Eleonora Aronica,
Ettore Beghi, Ingmar Blümcke, Torbjörn Tomson,
Harry V. Vinters, Solomon L. Moshé
1 Overview: Epidemiology and Pathology of Seizures
and Epilepsy 1
Solomon L. Moshé, Alexis Arzimanoglou,
W . Allen Hauser
2 Epilepsy: Historical Perspectives 3
Simon Shorvon, Peter Wolf
3 Incidence and Prevalence of Seizures and Epilepsy 8
W. Allen Hauser, Giorgia Giussani, Ettore Beghi
4 Epidemiology of Epilepsy in Low- and Middle-Income
Countries 17
Charles R. Newton
5 Etiology and Risk Factors for Seizures and Epilepsy 22
Symon M. Kariuki, Dale C. Hesdorffer,
Charles R. Newton
6 The Comorbidities in Epilepsy 32
Bastien Rioux, Carol Camfield, Josemir W. Sander,
Mark R. Keezer
7 Natural History and Prognosis of Epilepsy 45
Ettore Beghi, Peter R. Camfield
8 Epidemiology of Acute Symptomatic Seizures 54
W. Allen Hauser, Giorgia Giussani, Ettore Beghi
9 Seizure Precipitants 60
Eylert Brodtkorb, Christian Samsonsen,
Sheryl R. Haut
10 The Mortality of Epilepsy 66
Samden D. Lhatoo, Torbjörn Tomson
11 General Neuropathology of Epilepsy 76
Ingmar BlĂĽmcke
12 Neuropathology of Hippocampal Sclerosis 80
Maria Thom, Roland Coras
13 Neuropathology of Developmental Disorders
Associated With Epilepsy 88
Harvey B. Sarnat, Ingmar BlĂĽmcke, Hajime Miyata,
Harry V . Vinters
14 Neuropathology of Brain Tumors Associated
With Epilepsy 105
Eleonora Aronica, Albert J. Becker,
Angelika MĂĽhlebner
15 Neuropathology of Vascular Lesions Associated
With Epilepsy 123
Hajime Miyata, Eleonora Aronica
Section Editors: Renzo Guerrini, Samuel F. Berkovic,
Ruth Ottman, Jeffrey L. Noebels, Solomon L. Moshé
16 Overview: Genetics in Epilepsy 141
Aristea S. Galanopoulou, Renzo Guerrini
17 Genetic Epidemiology in Epilepsy 142
Colin A. Ellis, Ruth Ottman
18 Genetic Architecture of the Epilepsies 154
Karen L. Oliver, Samuel F. Berkovic
19 Single Gene Epilepsies 160
Valerio Conti, Renzo Guerrini
20 How to Interpret and Act on Clinical Exomes
in Epilepsy 174
Yoshiteru Azuma, Naomichi Matsumoto
21 Familial Epilepsies in the First Year of Life 180
Monica Cooper, Mitsuhiro Kato
22 Developmental and Epileptic Encephalopathies 185
Amy McTague, Renzo Guerrini
23 Genetic Generalized Epilepsies 199
Antonietta Coppola, Carla Marini
24 Genetic Encephalopathies With Epilepsy as a
Main Feature 211
Andreas Brunklaus, Danique R. M. Vlaskamp,
Floor E. Jansen
25 Genetic Testing and Counseling for the Epilepsies 223
Melissa Wasserstein, Katie Gallagher , Beth Rosen Sheidley
Section Editors: Istvan Mody, Annamaria Vezzani, Asla
Pitkänen, Hal Blumenfeld, Ivan Soltesz, Jerome Engel Jr
26 Overview: Neurobiology of Epilepsy 231
Istvan Mody, Ivan Soltesz, Annamaria Vezzani,
Jerome Engel Jr
27 Transcriptional Channelopathies in Genetic
and Acquired Epilepsies 232
Mala M. Shah, Douglas A. Coulter
28 Principal Cell Heterogeneity in Malformations
of Cortical Development and Acquired Epilepsy 241
Fraser T. Sparks, Alfonso Represa, Attila Losonczy,
Ivan Soltesz
29 Mechanisms of Neuronal Excitation Leading
to Synchrony 254
Laura A. Ewell, Kevin J. Staley
CONTENTSx Contents
30 Interneuron Diversity in Epilepsy: Challenges
and Progress 264
Carolyn R. Houser, Scott C. Baraban, GĂĽnther Sperk
31 Mechanisms of Neuronal Inhibition Leading
to Synchrony 277
Andrew Trevelyan, Kyle P. Lillis
32 Neurons and Circuits During Brain Development 286
Roustem Khazipov, Frances E. Jensen
33 Metabolism, Reactive Oxygen Species, and Epilepsy 295
Manisha Patel, Matthew Walker
34 Dendritic Mechanisms of Excitability 300
Heinz Beck, Yoel Yaari
35 Thalamocortical Organization and Function:
New Insights and Implications for Epilepsy 309
Frances S. Cho, Jeanne T. Paz
36 Mechanisms of Seizure Initiation and Propagation 321
Steven Tobochnik, Pariya Salami, Sydney S. Cash,
Catherine A. Schevon
37 Seizures and Networks in the Human Focal Epilepsies:
Beyond the Animal Models 335
Fabrice Bartolomei, Vadym Gnatkovsky,
Stanislas Lagarde, Marco de Curtis
38 Temporal Coordination: A Key to Understand
Cognitive and Behavioral Deficits in Epilepsy 344
Pierre-Pascal Lenck-Santini, Liset Menendez de la Prida
39 Epilepsy and Consciousness 361
Fabrice Bartolomei, Hal Blumenfeld
40 Activating and Recording Neuronal Ensembles 377
Marco Ledri, Fredrik Berglind, Merab Kokaia
41 Genetically Encoded Probes for Optical Measurement
of Neuronal Excitability and Synchrony 390
Carlos Portera-Cailliau, Istvan Mody
42 Fast Rhythms in Epilepsies 397
Premysl Jiruska, Anatol Bragin, Richard J. Staba
43 Miniaturized Microscopy as a Tool to Track Neuronal
Population Dynamics in Epilepsy Models 410
Daniel Aharoni, Peyman Golshani
44 Seizure Control Through Closed-Loop Systems 423
Martha L. Streng, Esther Krook-Magnuson
45 Biomarkers 434
Simona Balestrini, Asla Pitkänen, Matthias J. Koepp
46 Comorbidities as Prognostic Factors for
Epileptogenesis 454
Wolfgang Löscher, Carl E. Stafstrom
47 Use of Human Pluripotent Stem Cells in Epilepsy
Research 465
Jack M. Parent, Lori L. Isom
48 Novel Roles of Myelination in Neural Circuit Plasticity
and Implications for Epilepsy 482
Manasi Iyer, J. Bradley Zuchero
49 Role of Dysfunctional Astrocytes in Epileptogenesis 495
Christian Steinhäuser, Karen S. Wilcox
50 Neurovascular Inflammation in Epilepsy 506
Nicola Marchi, Annamaria Vezzani
51 The Blood–Brain Barrier and Epilepsies 517
E. A. van Vliet, Alon Friedman
52 The mTOR Pathway in Epileptogenesis 523
Emilio Russo, Michael Wong
53 Epigenetic Mechanisms in Epilepsy 533
Olivia R. Hoffman, Avtar Roopra, David C. Henshall
54 Purinergic Signaling in Epilepsy 544
Tobias Engel, Manvitha Kuchukulla, Detlev Boison
55 Neurotrophic Factors in Epilepsy 554
James O. McNamara, Michele Simonato
56 Neurogenesis in Epilepsy 563
Steve Danzer, Jenny Hsieh
57 Somatic Mosaicism in Focal Malformations of
Cortical Development 575
Sara Baldassari, Katja Kobow, Stéphanie Baulac
58 The Microbiota–Gut–Brain Axis and Epilepsy 582
Stefanie Prast-Nielsen, John F. Cryan
Section Editors: Aristea S. Galanopoulou, John M. Stern,
Andrew G. Herzog, Mark Quigg, Sheryl R. Haut,
Ivanka Savic, Terence J. O’Brien, Samden D. Lhatoo,
Solomon L. Moshé, Jerome Engel Jr
59 Overview: Translational and Clinical Biology
of Seizures and Epilepsy 591
Aristea S. Galanopoulou, John M. Stern
60 Refinement of Rodent Models of Seizures and
Epilepsy 593
John G. R. Jefferys, Mark J. Prescott
61 What do Models Model in Epilepsy? 600
Aristea S. Galanopoulou, Solomon L. Moshé
62 Translational Epilepsy Research: Progress, Challenges,
and Future 611
Aristea S. Galanopoulou, Jacqueline A. French,
Terence J. O’Brien, Michele Simonato
63 Age and Sex in the Neurobiology of Epilepsies
in Animal Models 616
Ozlem Akman, Kevin M. Kelly
64 Gender in Clinical Biology of Epilepsy 632
Barbara S. Koppel, Ivanka Savic
65 Age and Clinical Biology of Epilepsy: Adults 637
Joseph I. Sirven
66 Age and Clinical Biology of Epilepsy: Infants 644
Douglas R. Nordli Jr, Chalongchai Phitsanuwong
67 Chronobiology of Epilepsy 650
Philippa J. Karoly, Vikram R. Rao, Maxime Baud
68 Sleep and Epilepsy 669
Carl W. Bazil, Gordon F. Buchanan
69 Breathing and Autonomic Disturbances During
Seizures 685
Nuria Lacuey Lecumberri, Brian D. Moseley,
Samden D. Lhatoo
70 Sudden Unexpected Death in Epilepsy (SUDEP) 700
Philippe Ryvlin, Mark Stewart, Elizabeth J. Donner
71 Stress and Epilepsy 716
Ivanka Savic, Sheryl R. Haut, Marian Joëls
72 Seizures and Epilepsy in General Medical Disorders 724
Timothy E. Welty, David G. Vossler Contents xi
73 Medical Conditions in Children With Epilepsy 743
M. Scott Perry, Michael S. Duchowny
74 Neurodegenerative Disorders and Epileptogenesis 751
Victor Ferastraoaru, Patricia G. Saletti,
Aristea S. Galanopoulou
75 Anesthesia for Procedures in Patients With Epilepsy 762
Susana Vacas, Barbara M. van de Wiele
76 Hormone Changes in Epilepsy 771
Catherine A. Christian-Hinman, Cynthia L. Harden
77 Effects of Hormones on Seizure Expression 779
Torbjörn Bäckström, David Bäckström, Suchitra Joshi
78 Disorders of Reproduction and Fertility in Epilepsy 793
Andrew G. Herzog, Jouko I. T. Isojarvi
79 Sexuality in Epilepsy 806
Susan Duncan, Oliver Henning
80 Maternal Outcomes During Pregnancy in Women
With Epilepsy 815
Page B. Pennell, Torbjörn Tomson
81 Consequences of Seizures 821
Dipan C. Patel, Harald Sontheimer
82 Drug Resistance in Epilepsy 832
Wolfgang Löscher, Heidrun Potschka, Lina Jonsson,
Sanjay M. Sisodiya, Annamaria Vezzani
Section Editors: Renzo Guerrini, John M. Stern, Peter
Wolf, Robert S. Fisher, Philippe Kahane, Fernando
Cendes, Aristea S. Galanopoulou, Jerome Engel Jr
83 Overview: Phenomenology of Seizures 853
Jerome Engel Jr, Solomon L. Moshé
84 Classification of Epileptic Seizures 855
Robert S. Fisher, Jerome Engel Jr
85 Awareness in Seizures 866
John M. Stern, Hal Blumenfeld
86 Automatisms in Seizures 872
Andreas Schulze-Bonhage, Laura Tassi
87 Hyperkinetic Seizures 887
Paolo Tinuper, Lino Nobili
88 Autonomic Auras and Seizures 893
Nuria Lacuey Lecumberri, James J. Riviello Jr,
Samden D. Lhatoo
89 Cognitive Seizures 899
Elza Márcia Targas Yacubian, Peter Wolf
90 Affective Seizures 908
Khalil Ali, Tarek Ali, S. M. Amza Ali
91 Neocortical Sensory Seizures 917
Paul C. Van Ness, Ronald P . Lesser, Michael S. Duchowny
92 Typical Absence Seizures 928
Jeanne Benoit, Yoshimi Sogawa, William P . Welch,
Pierre Thomas
93 Atypical Absence Seizures 941
Miguel A. Cortez, Christian M. Korff
94 Myoclonic Absence Seizures 951
Kenneth A. Myers, Gaetano Cantalupo,
Carlo Alberto Tassinari
95 Seizures With Eyelid Myoclonia 956
Cristina Yip Go, O. Carter Snead III
96 Atonic Seizures 963
Roberto Michelucci, Hiroki Nariai
97 Clonic Seizures 971
Jillian L. Rosengard, Akio Ikeda
98 Epileptic Spasms 974
Lucia Fusco, Marta Elena Santarone, Puja Patel
99 Myoclonic, Myoclonic–Atonic, and Myoclonic
Tonic–Clonic Seizures 985
Guido Rubboli, Hirokazu Oguni
100 T onic Seizures 1007

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