Every now and then in paediatrics (or when you’re the unlucky on-call medic asked to review the child in the ER), you’ll meet a kid who looks like they lost a fight with a purple marker — palpable purpura on the legs, crying from abdominal pain, and passing Coca-Cola-colored urine.
If that rings a bell louder than your ward call buzzer, congratulations — you’ve just met Henoch-Schönlein Purpura (HSP). 🎯
💡 What is HSP, Really?
Henoch-Schönlein Purpura, now more formally called IgA Vasculitis, is the most common small-vessel vasculitis in children. It’s an IgA immune complex–mediated condition that loves to mess with skin, joints, GI tract, and kidneys — because why stop at one system when you can hit four?
I still remember a 6-year-old boy at SKBZ Hospital, Quetta who came in with colicky abdominal pain and what his mother called “mosquito bites” on the legs — except those bites didn’t blanch, didn’t itch, and were multiplying like residents during a grand round. Turns out, the bugs were innocent. The kidneys, not so much.

HSP Mnemonic – “PAAR the IgA”
| Letter | System Involved | Clinical Feature |
|---|---|---|
| P | Purpura (skin) | Palpable purpura, typically on buttocks & lower limbs |
| A | Arthralgia/Arthritis (joints) | Often knees & ankles; transient and non-deforming |
| A | Abdominal pain (GI) | Colicky pain, GI bleeding, intussusception risk |
| R | Renal involvement | Hematuria, proteinuria; can progress to nephritis |
🔍 Bonus: Always remember IgA deposition in vessel walls on biopsy – always asked in the exam!
🔬 Diagnostic Pearls
- Palpable purpura is a must-have. If there’s no rash, rethink the dx.
- Labs: ↑ serum IgA, hematuria ± proteinuria on urine dipstick
- Skin or renal biopsy (if needed): IgA deposition in small vessels
In Quetta, we once had a case misdiagnosed as ITP (because “rash and low platelets” was the first reflex). But turns out — platelets were normal, urine was dirty, and voila — classic HSP.
🧠 For the USMLE/MRCP Exam: Rapid Fire Recap
- Type III Hypersensitivity
- Most common vasculitis in kids
- Post-URTI trigger often present
- IgA in vessels + glomeruli
- GI complication to fear: Intussusception
Dr. Aurangzaib Qambrani
(MBBS, RMP, PLAB, MRCP-UK 1)
Sheikh Khalifa Bin Zayed Hospital, Quetta
General Medicine | Gastroenterology | CCU

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